FRACTAL STORM (SELF-LAID OPTIONS

During the LSD-certain crystal composition, the facet chain on the lid residue L209EL2 kinds in depth hydrophobic contacts with both LSD and bordering residues in TMs III, IV, and V (Determine 4C). If the lid moved aside to reveal the binding pocket in simulation, many of those contacts broke. We thus hypothesized that L209EL2 acts being a latch, c